It involves mainly young adults
Genetic factor that causes this disease- HLA B5 and HLA B51
CLINICAL FEATURES
- Major i.e. RECURRENT ORAL ULCERATION
2. Minor i.e. RECURRENT GENITAL ULCER
EYE LESION- UVEITIS( Panuveitis)
SKIN LESION- Erythema Nodosum
Other features-
- Deep Vein Thrombosis
- Superficial thrombophlebitis
- Arthritis- Non corrosive
- CNS involvement- mainly parenchyma
PATHOGENESIS
- Auto antibody (ASCA- anti sacharomyces cervesiae Antibody)- Enolase of endothelial cells
DIAGNOSIS
Pathergy Test- Non- specific inflammatory reactivity to any scratches or intradermal saline infusion
TREATMENT
Mucous membrane involvement may respond to TOPICAL STEROIDS
In serous cases- THALIDOMIDE
